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> 95% by SDS PAGE 

Short term (30 days) 4?C 

Long term at or below –20?C

For Research Use Only. Not for use in Diagnostic Procedures

A murine monoclonal antibody to an epitope in the C3c domain of C3.

This monoclonal antibody was raised against purified human C. It is specific for an antigen expressed on the C3c domain of C3 and therefore reactive to C3 and all C3c-containing fragments of C3.

Quidel's C3 (C3c) monoclonal antibody has been used in a variety of experimental techniques including EIA, Western Blot, RIA, Hemagglutination and Immunohistochemistry. Please contact Quidel Technical Support for details on these or other applications.

The human complement component C3 consists of two disulfide bonded subunits (Alpha 115,000 kD and Beta 75,000 kD). The concentration of C3 in serum is approximately 1.25 +/– 0.52 mg/ml. Under normal conditions, activation of either of the complement pathways leads to C3 convertases, which cleave C3 into two fragments C3a, an anaphylatoxin, and C3b. The C3b fragment has many biologic functionsincluding promotion of phagocytosis and participation as a structural component of both the C3 and C5 convertase enzymes. These processes are under stringent control in vivo

 Please contact Quidel Specialty Products Technical Services for application specific information.