Category: Preclinical MRI probes
– Gd content: one Gd atom per molecule
– Hydrodynamic size: diameter is 2-3 nm
– Molecular weight: 3.5 kDa
– Dose: due to high relaxivity of P846, the injected dose is lower than that of conventional contrast agent like Gd-DOTA
Recommended dose: 50 μmol/kg = 2.5 μL/g
Example: for a 30g body weight mouse, injection volume is 75 μL
– Relaxivities (s-1.mM-1, 37°C, Human Albumin Serum 4%)
1.5
2.35
3.0
4.7
7.1
r1
32
28
24
15
11
41
39
34
31
29
– In vitro quantification techniques: P846 is a Gd-based contrast agent. Gd can be dosed by ICP-AES or ICP-MS. Another way to quantify Gd chelates is by T1 or T2 relaxometry, with assumption of r1 or r2.
– Volume: 450 μL (5 mice dose approx.)
– Other animal species: please contact us
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