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Anti-FANCM Antibody

品牌：Antibodies

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规格：50μl

货期：

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Anti-FANCM Antibody

商品详情参考文献相关资料

Overview

Name:	Anti-FANCM Antibody See all FANCM primary antibodies
Description:	Rabbit polyclonal antibody to FANCM.
Applications:	WB, IF
Dilutions:	WB: 1:500 - 1:2000, IF: 1:50 - 1:100.
Reactivity:	Human
Immunogen:	Recombinant protein of human FANCM.
Protein Length:	2048
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434).
Sequence Similarities:	Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.
Post-Translational Modification:	Phosphorylated; hyperphosphorylated in response to genotoxic stress.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 57697?Human Omim: 609644?Human SwissProt: Q8IYD8?Human Unigene: 509229?Human
Synonyms:	ATP-dependent RNA helicase FANCM Antibody FAAP250 Antibody FANCM Antibody Fanconi anemia group M protein Antibody fanconi anemia-associated polypeptide of 250 kDa Antibody KIAA1596 Antibody Protein Hef ortholog Antibody
Information:	Target information shown above is from the UniProt Consortium.